CLEANING-IN-PLACE SYSTEMS IN PHARMA MANUFACTURING
CIP/SIP Systems in Pharmaceutical manufacturing
Thanks to the advent of CIP (Clean-In-Place) and SIP (Sterilization-In-Place) technologies, sealed systems such as pipes, vessels or process equipment in technical process plants can be cleanded without the need to disassemble the systems. This is a great time-saving advantage in industrial sectors where fixed and regular cleaning was required, such as pharmaceutical industry, food and beverage.
CIP - CLEANING IN PLACE
The cleaning method allows the internal surfaces of a sealed system to be entirely cleaned without disassembly or with disassembly of a limited number of components. The CIP process is completely automatic, to respect defined process times and parameters.
The cleaning operation -with temperatures up to 100°- is performed through a series of steps with turbulent flows: Pre-rinsing, Cleaning with lye (typically NaOH), Rinsing off the lye with water, Cleaning with acid, Rinsing off the acid with water, Thermal or chemical sterilization, Final water rinsing.
SIP - STERILIZATION IN PLACE
Steam sterilization of the pharmaceutical processing plant takes place after CIP, as a further sterilzation step. It is an indispensable operation in areas where germ reduction plays a prime role. SIP ensures, in fact, that any microorganism still active in the plant is erased. The system can use hot water or saturated pure steam at high temperatures (> 120 °C) and about 2 bar, for a variable period (>60 minutes) depending on the specific application.
Bram-Cor Movable CIP units - The mobile Clean-In-Place Stations can have easy positioning in production lines
BRAM-COR CIP SYSTEMS, WITH MOBILE OR FIXED UNITS
BRAM-COR Clean in Place systems are designed to fully meet cGMPs requirements in cleaning and sterilizing practices commonly applied in pharmaceutical process lines and plants. With an extensive range of systems, BRAM-COR meets the most diversified needs, with mobile and fixed stations, with dedicated solutions that were also the challenges posed by sterilization with superheated steam, thanks to a specific and calibrated design.
Bram-Cor Clean-In-Place (CIP) Systems - customized fixed stations
Each BRAM-COR CIP/SIP equipment is designed (in single or multitank configuration) to achieve the most effective and easily validable cleaning systems, starting from: Type and size of equipment to wash, Required type of water and chemical agent, Pharmaceutical product to remove, Cleaning nozzles type, Washing sequence, automation level.
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