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IV (infusion) bags and bottles hanging on poles during a real surgery
IV (infusion) bags and bottles hanging on poles during a real surgery

Our site clarifies some aspects related to the use of Water for Injection and grade waters, specially to produce IV fluids and parenteral solutions. Although the correct water treatment system is the basis for the final quality of any pharmaceutical solution, there are factual differences of evaluation regarding the choice of technologies.

Inside Water for Injection definition

What WFI Water for Injection means in Europe rather than in Japan or US? Which one is better between vapor compression or multiple effect distillation? Reverse osmosis systems can produce cold WFI? There are differences between sterile and bacteriostatic wfi? What are thevalues ofreverseosmosis, ultrafiltration or UV treatment? All these technologies are part of our core business, so these pages offer a concrete knowledge of the leading considerations in pharmaceutical field. We hope to be useful not only for our customers, but also for the many students asking us questions about the different grades of water used in biotechnologies and in pharmaceutical applications. To discover all types of pharmaceutical water in this website: WFI and compendial waters in pharmacopoeias

Inside Water for Injection production

To produce Water for Injection (WFI) you need a distiller; USP admits also “a purification process that is equivalent or superior to distillation in the removal of chemicals and microorganisms” (like Reverse Osmosis coupled with electro-deionization, nanofiltration and, downstream, ultrafiltration). To discover how to get WFI in this website: Methods to produce Water for Injection

Water for Injection equipment manufacturing

Going to visit our main web site (, you can discover BRAM-COR expertise in many types of pharmaceutical equipment, from water treatment to processing and filling. Therefore WFI equipment manufacturing starts from those International Good Manufacturing Practices (cGMP) that are common to all BRAM-COR machinery.  It must be also considered that all the different Pharmacopoeias in the world are the baseline to BRAM-COR work. So, we have an infinity of customizations. Furthermore, we proudly remark that our equipment is entirely manufactured and customized in Italy. In fact, BRAM-COR experience and passion for stainless steel processing enable to care for quality in details. Moreover, energy saving concerns, sanitary quality and certifications, long-term reliability are a rule for BRAM-COR distillers and water treatment systems.

How the equipment produces WFI.

First of all, to discover how Vapor Compression Still (VCD) works: Vapor compression distillation process

Similarly, to discover how Multi Effect Distiller (MED) works: Multiple effect distillation process

Furthermore, to discover how reverse Osmosis + Ultrafiltration (RO+UF) works: Reverse Osmosis + Ultrafiltration system 

Direct link to BRAM-COR main website for specific equipment producing pharmaceutical / compendial waters:

PRTW Water Pretreatment System

CROSReverse Osmosis System

STMCVapor Compression Distiller

SMPTMultiple Effect Distiller

CPSGPure Steam Generator

Inside Water for Injection: the BRAM-COR global vision

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