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Our site clarifies some aspects related to the use of Water for Injection and other pharmaceutical grade waters, specially to produce IV fluids and parenteral solutions. When a water complies with the pharmacopoeias requirements is called compendial water. Although the correct water treatment system is the basis for the final quality of any pharmaceutical solution, there are factual differences of evaluation regarding the choice of technologies to produce each compendial water.

Water for Injection definition

What WFI Water for Injection means in Europe rather than in Japan or US? Which one is better between vapor compression or multiple effect distillation? Reverse osmosis systems can produce cold WFI? There are differences between sterile and bacteriostatic wfi? What are the values of reverse osmosis, ultrafiltration or UV treatment? All these technologies are part of our core business, so these pages offer a concrete knowledge of the leading considerations in pharmaceutical field. We hope to be useful not only for our customers, but also for the many students asking us questions about the different grades of water used in biotechnologies and in pharmaceutical applications. To discover all types of pharmaceutical water in this website: WFI and compendial waters in pharmacopoeias

Bram-Cor water Treatment Room

Water for Injection Systems

Water For Injection can be produced through distillation or through a downstream unit of ultrafiltration in a Reverse Osmosis system. Therefore, to produce Water for Injection (WFI) in a absolutely safe way, usually you need a distiller; USP admits also RO systems, such as “a purification process that is equivalent or superior to distillation in the removal of chemicals and microorganisms” (like Reverse Osmosis coupled with electro-deionization, nanofiltration and, downstream, ultrafiltration). To discover how to get WFI in this website: Methods to produce Water for Injection

DEC 2019, Bram-Cor main factory, Parma (Italy). Set of seven STMC distiller in construction. They will be delivered in the course of 2020
Bram-Cor main factory, Parma (Italy). Set of seven STMC distillers in construction. Today they are at the forefront of vaccine production.

Water for Injection equipment manufacturing

If you visit our main web site (, you can discover BRAM-COR expertise in many types of pharmaceutical equipment, from water treatment to processing and filling. Therefore WFI equipment manufacturing starts from those International Good Manufacturing Practices (cGMP) that are common to all BRAM-COR machinery. It must be also considered that all the different Pharmacopoeias in the world are the baseline to BRAM-COR work. So, we have an infinity of customizations. Furthermore, we proudly remark that our equipment is entirely manufactured and customized in Italy. In fact, BRAM-COR experience and passion for stainless steel processing enable to care for quality in details. Moreover, energy saving concerns, sanitary quality and certifications, long-term reliability are a rule for BRAM-COR distillers and water treatment systems.


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BRAM-COR Catalogue PDF viewer

Catalogue. Click on the image to see “at a glance” Bram-Cor equipment for pharmaceutical manufacturing.


How the equipment produces WFI

First of all, to discover how Vapor Compression Still (VCD) works: Vapor compression distillation process

Similarly, to discover how Multi Effect Distiller (MED) works: Multiple effect distillation process

Furthermore, to discover how reverse Osmosis + Ultrafiltration (RO+UF) works: Reverse Osmosis + Ultrafiltration system 

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