WATER FOR INJECTION SYSTEMS
proud to be AT the heart of the pharmaceutical manufacturing system
Water is an intrinsic component of all pharmaceutical formulations; without water there can be no preparations to make vaccines, IV Fluids, parenteral solutions, ointments, eye drops, antibiotics, creams and all drugs that require a solvent compatible with human nature. This BRAM-COR site clarifies some aspects related to the use of Water for Injection and other pharmaceutical grade waters, especially for the production of I.V. fluids and parenteral solutions.
Water for Injection definition
What is the meaning of “Water for Injection” in Europe rather than in Japan or US? Which one is better between vapor compression or multiple effect distillation? Reverse osmosis systems can produce cold WFI? There are differences between sterile and bacteriostatic wfi? What are the values of reverse osmosis, ultrafiltration or UV treatment? When a water meets the pharmacopoeias requirements of a pharmacopoeia is called a compendial water. Although the correct water treatment system is the basis for the final quality of any pharmaceutical solution, there are factual differences in evaluation of the technologies used to produce each compendial water. All these technologies are part of our core business, so these pages offer a concrete knowledge of the leading considerations in pharmaceutical field. Our hope is that this site will be useful not only to our customers, but also to the many students who ask us questions about the different grades of water used in biotechnologies and in pharmaceutical applications. To discover all types of pharmaceutical water in this website: WFI and compendial waters in pharmacopoeias
You can also read a “Guideline on the quality of water for pharmaceutical use” from EMA (European Medicines Agency) (Site source: https://www.ema.europa.eu/en/homepage)

Water for Injection distillers
Water For Injection can be produced through distillation or through a downstream unit of ultrafiltration in a Reverse Osmosis system. Therefore, to produce Water for Injection (WFI) in a absolutely safe way, usually you need a distiller; USP also allows RO systems, such as “a purification process that is equivalent or superior to distillation in the removal of chemicals and microorganisms” (like Reverse Osmosis coupled with electro-deionization, nanofiltration and, downstream, ultrafiltration). To discover how to get WFI in this website: Methods to produce Water for Injection
On the side: Bram-Cor main factory, Parma (Italy). Set of seven STMC distillers in construction. Today they are at the forefront of vaccine production.

BRAM-COR TECHNOLOGIES FOR WFI AND PW FORMULATIONS, INTRAVENOUS AND PARENTERAL SOLUTIONS
Water for Injection equipment manufacturing
WFI equipment is made in compliance with International Good Manufacturing Practices (cGMP), which are common to all BRAM-COR machines. It must also be remembered that all the different Pharmacopoeias in the world are the basis form BRAM-COR’s work. So we have an infinite number of customizations. Visit our main web site (bram-cor.com) to discover BRAM-COR’s expertise in many types of pharmaceutical equipment, from water treatment to processing and filling.
We are also proud to say that our equipment is entirely manufactured and customized in Italy. In fact, BRAM-COR experience and passion for working with stainless steel, allow usmto care for quality in every details. In addition, energy saving, sanitary quality and certifications, long-term reliability are the rule for BRAM-COR distillers and water treatment systems.
How the equipment produces WFI
- Firstly, to discover how Vapor Compression Still (VCD) works: Vapor Compression Distillation process
- Similarly, to discover how Multi Effect Distiller (MED) works: Multiple Effect Distillation process
- And also to discover how reverse Osmosis + Ultrafiltration (RO+UF) works: Reverse Osmosis + Ultrafiltration system
Videos from BRAM-COR YouTube Channel